Bretazenil was invented in 1988 but never made it through clinical testing. It exists today as a designer benzodiazepine drug (DBZD) popular for its euphoric and inebriating qualities. Buy Bretazenil Canada

This compound is classified as an imidazopyrrolobenzodiazepine — which is a subclass of the larger benzodiazepine family. Structurally, bretazenil is most similar to the benzodiazepine antidote — flumazenil — but the effects share more overlap with other members, including alprazolam and clonazepam.

Psychedelic drug researcher, David Nutt, once suggested this high-potency benzodiazepine could serve as an excellent jumping-off point for developing other social drugs.

Bretazenil differs from traditional 1,4-benzodiazepines by exerting its effects through a different mechanism of action. Data suggests this gives bretazenil a more benign adverse effects profile and less of a potential to cause physical dependence and withdrawal symptoms (unconfirmed). Buy Bretazenil USA

At the moment, bretazenil has not been clinically approved for use in the United States.

WHAT IS BRETAZENIL?

Bretazenil is a novel medication designed as an antidote for benzodiazepine overdose. It functions as a selective benzodiazepine receptor antagonist, which means it can reverse the sedative effects of benzodiazepines like diazepam and lorazepam. This compound is particularly significant in emergency medical settings, providing a critical intervention to counteract respiratory depression and sedation caused by excessive benzodiazepine use. By restoring normal consciousness and respiratory function, Bretazenil plays a vital role in improving patient outcomes during overdose incidents.

BUY BRETAZENIL ONLINE

Purchasing Bretazenil from our website ensures you receive a high-quality product that meets the highest safety standards. We provide comprehensive product information, including its uses and dosage instructions, making your buying experience straightforward and reliable. Our platform is designed to offer a secure and user-friendly environment for your transactions. Whether you’re a healthcare provider or an individual looking for Bretazenil, we cater to your needs with prompt customer support and fast shipping, allowing you to get the medication when you need it most.

HOW TO BUY BRETAZENIL?

Buying Bretazenil is a simple process on our website. First, navigate to the Bretazenil product page, where you will find detailed information about the medication. Select the quantity you require and add it to your cart. Once you’re ready to complete your purchase, proceed to checkout, where you will be asked to provide your shipping and payment information. We prioritize your privacy and security throughout the transaction. After placing your order, you will receive a confirmation email with tracking details for your convenience.

WHERE TO BUY BRETAZENIL?

Bretazenil is available through our website, where we offer a reliable and trustworthy source for this medication. It’s essential to purchase Bretazenil from reputable online pharmacies to ensure you receive a genuine product. We pride ourselves on sourcing our medications from licensed manufacturers, guaranteeing their authenticity and effectiveness. Our online platform is accessible from anywhere, making it easy for you to buy Bretazenil without the hassle of visiting a local pharmacy.

BUY BRETAZENIL NEAR ME

If you’re looking to buy Bretazenil near you, our website provides a convenient solution. While many pharmacies may not stock this specific medication, ordering online from our platform allows you to have it delivered directly to your doorstep, regardless of your location. This is especially useful in emergencies or when immediate access to the medication is required. We offer quick shipping options to ensure you receive your Bretazenil in a timely manner.

PURE BRETAZENIL

When purchasing Bretazenil, quality is paramount. We offer pure Bretazenil that has been rigorously tested for purity and potency. Our commitment to providing only high-quality medications ensures that you can trust the efficacy of the product. Pure Bretazenil is crucial for ensuring optimal results in emergency situations. Each batch undergoes stringent quality control measures, and you can find detailed certificates of analysis available for your review. Buy Bretazenil Canada

BRETAZENIL DOSAGE

Determining the appropriate dosage of Bretazenil depends on various factors, including the severity of the benzodiazepine overdose and individual patient characteristics. Typically, dosing should be guided by a healthcare professional. As a general guideline, the initial dose may range from 0.5 to 1 mg, administered intravenously, with subsequent doses given as needed based on the patient’s response. It’s crucial to follow the dosing recommendations provided by your healthcare provider to ensure safety and effectiveness. Buy Bretazenil Australia

HOW TO USE BRETAZENIL

Using Bretazenil effectively requires adherence to specific guidelines. It is administered intravenously in a medical setting, making it essential for trained healthcare professionals to handle the process. Before administering Bretazenil, the medical team will assess the patient’s condition and previous benzodiazepine use. Continuous monitoring of the patient’s response is necessary, as adjustments to the dosage may be required based on their recovery. Always ensure that Bretazenil is used as part of a comprehensive treatment plan supervised by qualified medical personnel. Order Bretazenil online

BRETAZENIL SPECS

Status	Research Chemical 🧪
Common Dosage	Unspecified
PubChem ID	107926
CAS#	84379-13-5

IUPAC Name: Tert-butyl(7S)-14-bromo-12oxo-2,4,11-triazatetracycloheptadeca-1(17),3,5,13,15-pentaene-5-carboxylate

Other Names: None.

Metabolism: Research on the pharmacokinetics of bretazenil is insufficient.

Duration of Effects: Short-acting (Unspecified duration). Research on this is unclear, but the elimination half-life is only 2.5 hours, suggesting its duration of effects is relatively fast compared to other benzodiazepines.

BENZODIAZEPINE DOSAGE EQUIVALENCY CALCULATOR

HOW DOES BRETAZENIL WORK?

Traditional benzodiazepines exert their effects through their interactions with GABA neurotransmitters, specifically GABA-A. They bind to GABA-A and produce an allosteric effect which potentiates the inhibitory effects of GABA-A on the neurons located in the brain and central nervous system (CNS). This, in turn, decreases the ability of neurons to fire and thus slows down overall brain activity. The slowdown is responsible for the typical benzodiazepine effects: reduction of anxiety and depression-related symptoms, as well as hypnotic and muscle relaxant properties. Buy Bretazenil Europe

During this process, traditional benzodiazepines bind to certain subunits within the GABA-A receptors and act as full agonists. Bretazenil has a different mechanism of action because it binds to a broader set of GABA-A subunits and acts as a partial agonist. Specifically, bretazenil binds to the α1, α2, α3, α4, α5, and α6 subunits, while 1,4- benzodiazepines only bind to α1, α2, α3, and α5 [1].

These differences are significant because, even though there is a lot about this process that isn’t yet understood, it has been shown that the variations benzodiazepines display when binding to the distinct GABA-A subunits account for the variety of effects that benzodiazepines can produce [2].

Additionally, being a partial agonist rather than a full agonist, when bretazenil binds to a GABA-A receptor, it only has partial efficacy relative to a full agonist. Lastly, certain studies contend that this decreased efficacy in relation to full agonists leads to bretazenil having a less severe adverse effects profile and a decreased potential to cause physical dependence [3].

IS BRETAZENIL SAFE?

Bretazenil has not been approved for commercial use, and limited clinical data makes it difficult to determine the risk level posed by it. However, we do have enough information to sketch out a rough idea. In general terms, the safety of bretazenil shouldn’t really be a concern for most people since it is not commercially available, and thus, procuring it is somewhat of an impossibility.

Bretazenil’s clinical development was discontinued not because it was considered unsafe for use but rather because there was little separation between its anxiolytic and sedative effects, making the drug clinically ineffective [4]. This wide spectrum of effects does make sense because, as explained before, bretazenil targets a broader range of GABA-A receptor subtypes.

However, there was positive evidence for bretazenil having a less dangerous side effects profile than traditional benzodiazepines, like diazepam, and less potential to cause physical dependence and withdrawal. It was also found that bretazenil was effective in treating generalized anxiety disorder (GAD) as well as panic disorder and had much better tolerability than 1,4- benzodiazepines [4].

BRETAZENIL SAFETY TIPS

Harm reduction is an important concept to be aware of when dealing with benzodiazepines, even ones with less potential to cause adverse effects like bretazenil.

Here are some simple harm-reduction tips for benzodiazepine drugs:

1. Don’t mix — Mixing benzodiazepines with other depressants (alcohol, GHB, phenibut, barbiturates, opiates) can be fatal.
2. Take frequent breaks — Benzodiazepines can form dependence quickly, so it’s important to stop using the drug periodically.
3. Know the dose — The dosage of benzos can vary substantially. Some drugs require 20 or 30 mg, others can be fatal in doses as low as 3 mg.
4. Know who should NOT use benzos for any reason — Benzodiazepines are significantly more dangerous in older people or those with certain medical conditions.
5. Test your drugs — If ordering benzos from unregistered vendors (online or street vendors). Order a benzo test kit to ensure your pills contain what you think they do.
6. Never snort or inject benzos — Not only does this provide no advantage, but it’s also extremely dangerous. Benzos should be taken orally.
7. Recognize the signs of addiction — Early warning signs are feeling like you’re not “yourself” without the drug or hiding your habits from loved ones.
8. Know where to go if you need help — Help is available for benzodiazepine addiction. You just have to ask for it. Lookup “addiction hotline” for more information where you live. (USA: 1-800-662-4357; Canada: 1-866-585-0445; UK: 0300-999-1212).

GENERAL RECOMMENDATIONS

With prescription drugs like benzodiazepines, users must always take pains to follow their prescriptions closely. Taking more than the recommended dose or using your prescription for a different reason than the one it was given to you is still misuse, and it will put you at more risk of developing an unhealthy habit with benzodiazepines.

Due to the significant risk factors involved with benzodiazepines, the general rule of thumb with doctors is to try and prescribe them for the shortest time frame possible; even then, there is a chance that physical dependence will develop. One study concluded that nearly one-third of individuals who take benzodiazepines for longer than four weeks become dependent and experience withdrawal symptoms upon cessation [5].

If one is considering a benzodiazepine prescription, it is essential to conduct proper research beforehand and be cognizant of the risks it can entail. It is no secret that doctors sometimes operate under dubious incentives which reward them for handing out prescriptions with minimal consideration. As a minimum, users should investigate non-pharmacological alternatives for their ailment —  like exercise, therapy, or plant-based medications — and give those a try.

BRETAZENIL DRUG INTERACTIONS

Opioids and alcohol should never be consumed if one is currently on a benzodiazepine prescription. When combined, these drugs dramatically raise the incidence of potentially fatal events, like respiratory depression, the leading cause of overdose deaths.

Depending on what CYP enzymes they are metabolized by, prescription medications are normally also affected by compounds that either induce or inhibit the functioning of said enzymes. This can lead to the benzodiazepines losing effectiveness, or it can make it so that the compound stays inside the body longer, raising the probability of adverse effects. Users should always be aware of possible CYP interactions when taking prescription benzodiazepines.

BRETAZENIL CONTRAINDICATIONS

Contraindications are a common way users unknowingly put themselves at risk. When taking benzodiazepines, always check the contraindications. Lastly, common ones include people with hepatic impairments, pregnant women, minors, driving or operating heavy machinery, etc.

SIMILAR BENZODIAZEPINES

Imidazobenzodiazepines like bretazenil have certain characteristics that set them apart. For instance, this subtype contains a series of compounds that act as both agonists and inverse agonists to the GABA-A receptors, and many of them are also considered to be partial, rather than full benzodiazepine receptor agonists [6].

EVT-201

Like bretazenil, EVT-201 is an imidazobenzodiazepine that exerts its mechanism of action through the standard GABA-A pathway. EVT-201 is also not approved as a medication but it is currently undergoing trials to serve treat sleep-related conditions.

Loprazolam

Loprazolam belongs in the same subtype as bretazenil and shares some of its pharmacological properties. Also, like a reduced incidence of adverse effects. However, loprazolam is intermediate-acting while bretazenil is short-acting.

FG-8205

There is not a lot of information available on FG-8205 but we do know that it shares a similar structure as bretazenil. It also exhibits a similar pharmacological profile with similar potency but less tendency towards sedation.

ALTERNATIVES TO BENZODIAZEPINES

When considering non-pharmacological alternatives to benzodiazepines, the best option is to go with a plant-based remedy.

The kava plant stands out as an obvious choice. It is an all-natural species of plant hailing from the pacific islands and has been shown to produce anxiolytic effects while having a relatively benign side effects profile [7].

 

FREQUENTLY ASKED QUESTIONS ABOUT BRETAZENIL

1. What is BretaZenil used for? BretaZenil is primarily used as an antidote for benzodiazepine overdose. It helps reverse the sedative effects of these drugs.
2. How is BretaZenil administered? It is typically administered via intravenous injection by a healthcare professional.
3. What are the side effects of BretaZenil? Common side effects may include headache, dizziness, nausea, and agitation.
4. Is BretaZenil safe for everyone? While generally safe. It may not be suitable for individuals with certain medical conditions or allergies. Always consult a healthcare provider before use.
5. Can BretaZenil be used for chronic anxiety? BretaZenil is not intended for chronic anxiety treatment. It is designed for acute situations involving overdose.
6. Where can I buy BretaZenil? BretaZenil can be obtained through licensed pharmacies with a prescription from a healthcare professional.

   CONCLUSION

   Purchasing BretaZenil online offers a convenient solution for those in need of this vital antidote for benzodiazepine overdose. However, it’s crucial to prioritize safety by selecting a reputable source that requires a valid prescription. Ensure that the online pharmacy you choose is licensed and verified, providing high-quality products. By doing so, you can rest assured that you are obtaining genuine BretaZenil, essential for effective treatment in emergencies. Always consult a healthcare professional to ensure proper usage and dosage for optimal outcomes.