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Benzodiazepines are a class of medications that work in the central nervous system and are used for a variety of medical conditions, such as anxiety, seizures, and for alcohol withdrawal. Benzodiazepines work by blocking excessive activity of nerves in the brain and other areas in the central nervous system. BENZODIAZEPINE POWDER.

As a class, benzodiazepines are similar in how they work in the brain but have different potencies and durations of actions. Because of this, some benzodiazepines work better than others in the treatment of particular conditions. Common examples of benzodiazepines include alprazolam (brand: Xanax), diazepam (brand: Valium) and lorazepam (brand: Ativan).

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• for sleep
• to induce relaxation and loss of memory of medical procedures or surgery
• to reduce anxiety (anxiolytic)
• panic disorders
• to treat or prevent seizures
• alcohol withdrawal treatment
• muscle relaxant

Benzodiazepines are a large drug class and have a long history of development, starting with the first FDA-approvals in the 1960s, chloridiazepoxide (Librium) and diazepam (Valium). There are many options available within the class, and most benzodiazepines are now available generically, making them affordable for most people.

All benzodiazepines are listed as DEA schedule IV controlled substances. As controlled substances, all benzodiazepines have the potential for abuse, addiction and diversion. BENZODIAZEPINE POWDER.

A Boxed Warning, the FDA’s most stringent safety warning, exists on all benzodiazepine product information. When benzodiazepines are combined with other sedatives, opiates or alcohol, the risk of serious side effects such as profound sedation, respiratory depression, coma, and death may occur. Abuse, misuse, addiction, physical dependence, and withdrawal reactions greatly increases with use of this drug class. he Centers for Disease Control and Prevention recommends that doctors avoid prescribing Xanax and other benzodiazepines with opioid pain medication whenever possible. BENZODIAZEPINE POWDER.

Flumazenil is a benzodiazepine antagonist antidote that can be given intravenously in the emergency setting to reverse the effects of a benzodiazepine overdose. BENZODIAZEPINE POWDER.

Table 1 lists U.S. generic and brand name benzodiazepines, their common uses and duration of action. Many of the brand name products have been discontinued by their manufacturers; however, equivalent, lower-cost generics are available for these brands.

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^{*The half-life is the amount of time it takes for half of the drug to be eliminated from the body. The shorter the half-life, the quicker the drug is eliminated, and the faster any bothersome side effects can subside.}

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Benzodiazepines work in the central nervous system. Selectively occupying certain protein areas in the brain called GABA-A receptors. There are three types of GABA (gamma-aminobutyric) receptors in the brain: GABA-A, GABA-B, and GABA-C. GABA is the main inhibitory neurotransmitter in the brain (a chemical that helps to block a nerve action). GABA helps to regulate movement, sight, anxiety, and many other brain functions.

Lastly, Benzodiazepines open GABA-activated chloride channels and allow chloride ions to enter the neuron. This action allows the neuron to become negatively charged and resistant to excitation. Which leads to the various anti-anxiety, sedative, or anti-seizure activity seen with these drugs.