Etizolam, also known by various trade names such as Etizest and Etilaam, is a benzodiazepine analog, specifically a thienodiazepine, and one of the first designer benzodiazepine drugs to show up in the market around 2011. Buy Etizolam Canada

Compared to other benzodiazepine drugs, etizolam displays a short-acting nature (5-7 hours) and considerable potency, with 1 mg roughly equivalent to 10 mg of diazepam.

Etizolam’s regulatory situation is somewhat of a mix-up. While it is an approved medication in places like Japan, Italy, and India, it has not received FDA approval in the United States as a medication. However, it is still legal to purchase online as a research chemical, which has led to a significant amount of misuse.

This has meant that although etizolam is federally unscheduled, individual states in the US like Alabama, Arkansas, Florida, Georgia, and others have scheduled it as a Schedule I compound, the most restrictive classification available. Buy Etizolam USA

WHAT IS ETIZOLAM?

Etizolam is a thienodiazepine, a compound closely related to benzodiazepines, primarily prescribed for managing anxiety, panic attacks, and sleep disorders. It works by enhancing the effects of gamma-aminobutyric acid (GABA), a neurotransmitter that calms the nervous system, providing a sense of relaxation and reducing tension. Unlike traditional benzodiazepines, Etizolam’s unique chemical structure may lead to slightly different effects and a potentially shorter duration of action, making it a distinct choice for therapeutic uses.

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ETIZOLAM SPECS

Status	Approved medication, but not in the United States.
Common Dosage	1–2 mg
PubChem ID	3307
CAS#	40054-69-1

IUPAC NAME

4-(2-Chlorophenyl)-2-ethyl-9-methyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine

OTHER NAMES

Etizest, Etilaam, Etizex, Depas, Sedekopan, Pasaden, Arophalm, Capsafe, Dezolam, Eticalm, Etidrale, Etisedan, Guperies, Medipeace, Mozun, Nonnerv, Palgin, Sylazepam. Buy Etizolam Europe

METABOLISM

The biotransformation of etizolam is extensive and involves both hydroxylation and conjugation. The main metabolite formed via 1′-hydroxylation is α-hydroxyetizolam and has an elimination half-life of around 8.2 hours [1]. This metabolic byproduct retains pharmacological activity comparable to that of the parent drug, indicating that metabolite action may contribute to etizolam’s clinical effects.

CYP3A4 is predicted to be the main CYP enzyme responsible for mediating etizolam metabolism.

CYP2C18 and CYP2C19 are also involved in the metabolic pathways [2]. The kidneys excrete the drug. Buy Etizolam New Zealand

DURATION OF EFFECTS

With a single oral dose of 0.5 mg, the average elimination half-life of etizolam is roughly 3.4 hours. However, this value may increase up to 17 hours, depending on the rate of metabolism.

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HOW DOES ETIZOLAM WORK?

Etizolam is known to exert its effects through the classic benzodiazepine pathway. This effect increases the natural inhibitory function of GABA and results in sedative, anxiolytic, and muscle-relaxant effects.

More specifically, etizolam is selectively a full, rather than a partial, GABA-A receptor agonist and enhances GABA-induced Cl- currents [3]. Etizolam shows high potency and affinity for the alpha-1 beta 2 gamma 2S subunit combination at GABA-A receptor sites. Alpha-1 receptors mediate the sedative effects of etizolam, while alpha-2 and alpha-3 mediate the anxiolytic effects [3]. Buy Etizolam in Austria

Furthermore, etizolam is also a specific antagonist at the platelet-activating factor receptor. It inhibits PAF-induced platelet aggregation by inhibiting PAF binding to the receptors on the platelet surface. PAF antagonists do not provoke an inflammatory response upon binding but rather block or lessen the effects of PAF [2]. Lastly, studies have demonstrated that etizolam mediates imipramine-like neuropharmacological and behavioral effects and exerts only minor effects on cognitive functioning. Buy Etizolam in Denmark

IS ETIZOLAM SAFE?

Etizolam, like all other benzodiazepines, carries significant risk. If it were an approved medication in the United States, it would likely receive a Schedule IV designation, which would entail that despite its recognized medical uses, it still carries the potential for misuse and dependence.

In general, when misuse is avoided, benzodiazepines are not likely to cause serious health-related events. However, the possibility of misuse is a very real factor that must be considered. The recent explosion in drug overdose deaths in the United States should serve as a stark reminder of this. Nonetheless, when it comes to etizolam, there is plenty of evidence to suggest that, among benzodiazepines, it has rare qualities that make it safer to use than most. Buy Etizolam in the Netherlands

SIDE EFFECTS OF ETIZOLAM

Etizolam is generally considered to be well tolerated when compared to other benzodiazepine compounds. However, it produces the usual range of side effects associated with benzodiazepines.

Regarding etizolam use, some of the most commonly reported adverse effects have been: drowsiness, sedation, muscle weakness, loss of coordination, fainting, headaches, confusion, depression, slurred speech, visual disturbances, changes in libido, and tremors. Buy Etizolam in Norway

In rare cases, etizolam has also been linked to skin lesions, blepharospasm (especially in women), and anterograde amnesia. However, etizolam has been found to have no effects on fertility, development, and teratogenicity [4]. Overall, its adverse effects profile is less significant than most benzodiazepines.

BENZODIAZEPINE WITHDRAWAL AND DEPENDENCE

As a possible consequence of benzodiazepine therapy, withdrawal symptoms and physical dependence are well-known factors. The full extent of these risks was unknown when they were first synthesized, and benzodiazepines were prescribed far too liberally. However, with time, doctors realized their mistakes and now take much care when it comes to hedging against this possibility. Buy Etizolam in Germany

In fact, it’s now standard practice for doctors to try and limit a benzodiazepine treatment to the shortest time frame, which will not affect the treatment’s likelihood of success. Doctors worry about the possibility of a benzodiazepine dependence because, if this were to happen, it would entail the patient would have to go through a long, drawn-out process of drug tapering to get off benzodiazepines safely. Drug tapering is considered a safe procedure when done under appropriate supervision, but complications can still develop.

Because of the dangers presented by benzodiazepine withdrawal, quitting these compounds “cold turkey” is not considered an option. Indeed, withdrawal symptoms stemming from benzodiazepines, as well as alcohol, are unique in that, if left untreated, they have the possibility of becoming fatal.

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However, when it comes to etizolam, it seems that the particular qualities present in this compound make it less likely to engender dependence, although, obviously, it is still a possibility which becomes likelier the more the compound is taken.

In a rat study that compared etizolam to lorazepam, it was found that etizolam had fewer chances of resulting in tolerance and dependence. It was also found that rats developed a tolerance to the anticonvulsant actions of lorazepam but not those of etizolam [5]. More studies are needed to confirm this characteristic of etizolam, but in the countries where it is available, such as India and Japan, the notion that etizolam is less liable to cause dependence is widespread. It has made etizolam one of the most prescribed benzodiazepines.

Nonetheless, etizolam’s potent, short-acting nature still has to be considered. It is well known that short-acting, potent benzodiazepines have more potential to engender dependence because they are more likely to cause abuse-related habits due to inter-dose withdrawal symptoms and other related factors.

ETIZOLAM SAFETY TIPS

It is important for prescription and recreational users to have basic harm reduction principles in mind to make smart decisions that will minimize their risk potential.

In this sense, prescription users should take special care to avoid any misuse, the most significant factor when it comes to benzodiazepine-related health events. This does not only mean avoiding recreational use but following your prescriptions to the letter and not altering anything about them.

Prescription users would also be wise to limit both the quantity and duration of their benzodiazepine treatment. The longer a drug is consumed, and the more of it is consumed, the likelier a dependence will form.

And when it comes to recreational users, there are also a few rules to stick by. They should try their hardest not to combine potent pharmacological drugs, which include alcohol, and especially more so if both compounds happen to have central nervous system-depressant properties. It is also a good idea to let a friend know if you will be taking something. Lastly, when it comes to benzodiazepines, recreational users should try to procure flumazenil and learn how to use it. Flumazenil is a benzodiazepine receptor antagonist, which means it can work to reduce overdose symptoms within the body, but only for benzodiazepines.

BENZODIAZEPINE HARM REDUCTION TIPS

1. 🥣 Don’t mix — Mixing benzodiazepines with other depressants (alcohol, GHB, phenibut, barbiturates, opiates) can be fatal.
2. ⏳ Take frequent breaks or plan for a short treatment span — Benzodiazepines can form dependence quickly, so it’s important to stop using the drug periodically.
3. 🥄 Always stick to the proper dose — The dosage of benzos can vary substantially. Some drugs require 20 or 30 mg; others can be fatal in doses as low as 3 mg.
4. 💊 Be aware of contraindications — Benzodiazepines are significantly more dangerous in older people or those with certain medical conditions.
5. 🧪 Test your drugs — If ordering benzos from unregistered vendors (online or street vendors), order a benzo test kit to ensure your pills contain what you think they do.
6. 💉 Never snort or inject benzos — Not only does this provide no advantage, but it’s also extremely dangerous. Benzos should be taken orally.
7. 🌧 Recognize the signs of addiction — Early warning signs are feeling like you’re not “yourself” without the drug or hiding your habits from loved ones.
8. ⚖️ Understand the laws where you live — In most parts of the world, benzodiazepines are only considered legal if given a prescription by a medical doctor.
9. 📞 Know where to go if you need help — Help is available for benzodiazepine addiction; you just have to ask for it. Look up “addiction hotline” for more information where you live. (USA: 1-800-662-4357; Canada: 1-866-585-0445; UK: 0300-999-1212).

ETIZOLAM DRUG INTERACTIONS

As mentioned before, etizolam should never be mixed with a compound that depresses the CNS, even if it’s a herbal compound like the kratom plant. Concomitant use of CNS depressants puts the user at risk of respiratory depression, the leading cause of death among drug overdoses.

Also, as a compound whose metabolism is mediated by the CYP enzyme system, etizolam users should be aware of possible CYP drug interactions.

Many compounds can interfere with the proper functioning of a given CYP enzyme, which means that the metabolism of any drug mediated by said enzyme would be affected. This could occur through inhibition, which would make metabolism less efficient and lead to an increased incidence of side effects, or it could happen through induction, which would entail an increased rate of metabolic clearance that would, in turn, make the compound less effective.

ETIZOLAM CONTRAINDICATIONS

Etizolam is contraindicated in patients with the following factors:

• Firstly, Increased eye pressure
• Secondly, Sleep disorders
• Thirdly, Hepatic impairment
• Fourthly, Porphyria
• In continuation, Lung disease
• Furthermore, Hypersensitivity to benzodiazepines
• Lastly, Pregnancy and lactation

ETIZOLAM DOSAGE

According to English authorities, the proper dosage quantities of etizolam can be found below:

• Firstly, Anxiety-related disorders: 0.25-0.5 mg twice daily
• Secondly, Panic-related disorders: 0.5 mg twice daily
• Thirdly, Insomnia: 1-2 mg daily
• Lastly, Maximum daily dosage: 3 mg

Anything over 2 mg is considered dangerous and should be avoided at all costs.

SIMILAR BENZODIAZEPINES

As they might want to switch medication, benzodiazepine users should be aware of what other compounds exist that have similar properties to their chosen benzodiazepine.

METIZOLAM

Metizolam —also a designer benzodiazepine compound —is one of the active metabolites of etizolam and is known to have a comparable chemical structure and a similar profile of effects. However, they’re slightly different in terms of pharmacokinetics, as metizolam has a shorter duration of action.

BENTAZEPAM

Bentazepam is another member of the thienobenzodiazepine subclass, which means it has a similar structure to etizolam and roughly comparable effects. However, it does not have the pharmacological particularities unique to etizolam. Nonetheless, their pharmacokinetics are comparable as both compounds have almost identical elimination half-lives.

NATURAL ALTERNATIVES OF BENZODIAZEPINES

Natural benzodiazepine alternatives are essential because, in some instances, users might prefer sacrificing potency to medicate themselves with a compound that offers less chance of forming a physical dependency and a more benign side effects profile.

KAVA

The kava plant has been found to contain active ingredients called kavalactones, which interact with GABA-A receptors to produce anxiolytic and sedative effects [6]. These effects are very similar to benzodiazepines.

However, kavalactones don’t accomplish their effects through the same mechanism of action as pharmacological benzodiazepines.

KRATOM

Kratom has become a popular herbal compound in recent years due to its wide breadth of natural pharmacological effects. In low doses, kratom acts as a stimulant and a euphoric, while in mid-to-high doses, it can produce anxiolytic and sedative effects.

It also has other uses, like treating withdrawal symptoms, as a sleeping support agent, and even as a weight-loss supplement [7].

However, kratom does have the potential for physical dependence, although to a lesser degree than prescription drugs.

FREQUENTLY ASKED QUESTIONS ABOUT ETIZOLAM

1. What is Etizolam?

Etizolam is a thienodiazepine, chemically similar to benzodiazepines, used to treat anxiety, insomnia, and panic disorders.

2. Is Etizolam legal?

Legality varies by country. In some regions, it is prescription-only, while in others it may be restricted or controlled.

3. How does Etizolam work?

Etizolam acts on the central nervous system, producing calming effects by enhancing GABA, a neurotransmitter.

4. What is the typical dosage?

Dosage depends on individual factors. Common prescriptions range from 0.5 mg to 1 mg.

5. What are the side effects?

Side effects include drowsiness, muscle relaxation, and potential dependency.

6. Can I use Etizolam long-term?

Long-term use is generally discouraged due to risks of dependence and tolerance.

7. How does Etizolam compare to benzodiazepines?

Etizolam is structurally similar but has unique effects and may work faster with a shorter half-life.

8. What is the onset time of Etizolam?
Effects are usually felt within 30–60 minutes after ingestion.

9. How should Etizolam be stored?
Store in a cool, dry place, away from children and pets.

10. Can Etizolam cause withdrawal symptoms?
Yes, especially with long-term use. Symptoms may include anxiety, agitation, and insomnia.

11. Is Etizolam addictive?

It can be habit-forming, so caution is advised, particularly with regular use.

12. Can Etizolam be taken with other medications?
Consult a healthcare provider, as Etizolam can interact with other CNS depressants.

13. What should I do if I miss a dose?
Take the missed dose as soon as possible, but skip it if the next dose is soon.

14. Is Etizolam safe during pregnancy?
The use of Etizolam during pregnancy is generally not recommended.

15. Can I drive after taking Etizolam?
Driving or operating machinery is not advised due to its sedative effects.

16. How does Etizolam differ from Xanax?
Though similar in effects, Etizolam is a thienodiazepine, while Xanax (alprazolam) is a benzodiazepine with a different chemical structure.

17. Can Etizolam be used for panic attacks?

Yes, it is sometimes prescribed for panic disorders.

18. What should I do in case of an overdose?
Seek immediate medical help. Overdose symptoms include extreme drowsiness, confusion, and respiratory depression.

19. Is Etizolam safe for elderly patients?
Elderly individuals may be more sensitive to sedative effects and should use it with caution.

20. Can Etizolam be bought online?
In some countries, it may be available online, but legality and authenticity vary greatly by location.

CONCLUSION

Etizolam is a unique thienodiazepine with therapeutic benefits primarily for anxiety, insomnia, and related disorders. Its effects, similar to benzodiazepines, offer rapid relief but demand caution, as it may lead to dependency with prolonged use. While it holds potential for short-term mental health support, its use should be well-informed and monitored by a healthcare provider to avoid adverse effects and withdrawal risks. As more research on Etizolam emerges, it’s essential to stay updated and make informed, responsible choices for safe use.
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