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EVERYTHING YOU NEED TO KNOW ABOUT AVIZAFONE

Also known as Pro-Diazepam, avizafone is, as its name suggests, a water-soluble prodrug for diazepam, one of the most clinically successful benzodiazepines on the market. Buy Avizafone online

Prodrugs are compounds that may or may not have pharmacological properties of their own but are instead converted into the active form by the liver.

Once avizafone is ingested, enzymes in the liver turn the compound into diazepam (AKA Valium).

Strangely enough, the primary clinical use of avizafone has little to do with diazepam. Instead, it’s used as an antidote to poisoning stemming from organophosphate nerve agents like sarin gas, tabun, and soman [1]. It was initially developed by the French military to eliminate battlefield casualties caused by these destructive nerve agents. Buy Avizafone Canada

WHAT IS AVIZAFONE?

Avizafone is a benzodiazepine derivative primarily used as an antidote in emergency medicine to counteract nerve agent poisoning. As a prodrug of diazepam, Avizafone is converted in the body to active diazepam, which produces calming and anticonvulsant effects by enhancing the action of the neurotransmitter GABA. Its ability to relieve convulsions makes it essential in military and toxicology settings, especially for soldiers and first responders who may encounter nerve agents. Avizafone is typically administered intramuscularly to ensure rapid onset in emergency situations, providing quick central nervous system suppression to manage seizures and related symptoms of poisoning.

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Avizafone, a specialized benzodiazepine prodrug, is highly sought after for its unique properties as a nerve agent antidote, particularly in emergency and military applications. Our website offers Avizafone directly from trusted suppliers, ensuring product quality and authenticity. When purchasing from us, you receive high-grade Avizafone, ideal for research or emergency preparation, with transparent information on dosages, storage, and usage instructions. Additionally, our secure purchasing process and discreet shipping options make ordering Avizafone from our website both safe and convenient.

HOW TO BUY AVIZAFONE?

To buy Avizafone from us, browse our selection, choose the required amount, and proceed to checkout with your details. We offer a seamless, user-friendly purchasing experience with multiple secure payment options. If you need assistance selecting the right amount or have questions regarding usage, our knowledgeable support team is available to guide you through the process and answer your questions. Buy Avizafone Australia

WHERE TO BUY AVIZAFONE?

Avizafone can be challenging to locate due to its specific uses and regulatory requirements, but our platform makes it accessible for those with the appropriate needs. You can rely on us as a reputable source for this benzodiazepine prodrug, sourced from verified suppliers and delivered in compliance with all relevant regulations. Rest assured, our platform provides Avizafone directly to your door, making the acquisition process easy and trustworthy.

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Finding Avizafone nearby may not always be possible, given its specialized nature. However, our online store allows you to bypass location limitations by ordering Avizafone with direct delivery options. With our platform, you can have Avizafone delivered to your home or facility, no matter where you are located.

PURE AVIZAFONE

Our Avizafone products are pure, high-quality formulations, ideal for those requiring accuracy and effectiveness in their research or emergency preparedness. Purity is critical in ensuring that Avizafone performs optimally in nerve agent antidote settings, which is why our suppliers prioritize rigorous quality checks. Choosing pure Avizafone ensures you’re getting a product that meets stringent standards, providing confidence and peace of mind. Buy Avizafone Europe

HOW TO TAKE AVIZAFONE

Avizafone is typically administered as an intramuscular injection and is usually done in emergency medical or military settings where rapid response is essential. It quickly metabolizes into diazepam in the body, aiding in the counteraction of toxic convulsions or other symptoms associated with nerve agent poisoning. Important: The dosage and administration method of Avizafone should only be conducted by trained professionals or under professional guidance, as improper use could lead to unintended effects. Be sure to consult with a healthcare professional for detailed instructions. Buy Avizafone USA

A BRIEF HISTORY OF AVIZAFONE

Developed for its powerful antidote effects against nerve agents, Avizafone has played an essential role in military and emergency medicine since its inception. As a prodrug of diazepam, Avizafone was designed to deliver rapid anticonvulsant effects during nerve agent exposure, with applications often specific to soldiers and first responders. The introduction of Avizafone marked a critical development in chemical defense, equipping military personnel and emergency responders with a fast-acting solution for managing toxic exposures. This history underlines Avizafone’s ongoing value as both a medical and protective asset in fields where the risk of toxic exposure is high. Buy Avizafone

 

This comprehensive overview provides an in-depth look into the functionality, applications, and methods of acquiring Avizafone for those with the necessary qualifications and usage needs.

AVIZAFONE SPECS

Status Not Used
Common Dosage Unspecified
PubChem ID 71968
CAS# 65617-86-9

IUPAC NAME

(2S)-2,6-diamino-N-{[(2-benzoyl-4-chlorophenyl)methylcarbamoyl]methyl}hexanamide

Metabolism

An aminopeptidase hydrolyzes Avizafone to liberate lysine and diazepam. The drug rapidly converts to diazepam because of enzymatic activation and deamination of metabolic byproducts in the blood [2].

BENZODIAZEPINE DOSAGE EQUIVALENCY CALCULATOR

I have

mg of
Substance 
I want to know the dose for
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**Caution:** Benzodiazepines have a narrow therapeutic window. Dose equivalents may not be accurate in higher doses.

This calculator does not substitute for clinical experience and is meant to serve only as a reference for determining oral benzodiazepine equivalence.

Please consult a medical practitioner before taking benzodiazepines.

HOW DOES AVIZAFONE WORK?

It’s been known for several years that benzodiazepine compounds can block seizures induced by organofluorophosphates. However, the benzodiazepine agent alone would not be enough to effectively counteract a poisoning of this kind. It would be necessary to administer a cocktail consisting of three drugs: an anticholinergic drug, an acetylcholinesterase reactivator, and an anticonvulsant (the benzodiazepine) [2].

In this sense, avizafone is never administered by itself; it is always used in conjunction with two other compounds. For these situations, the Sedat Company created a device known as the French Army Auto-Injector, which contains 2 mg of atropine, 350 mg of pralidoxime, and 20 mg of avizafone.

Diazepam achieves a higher maximum concentration when injected from a prodrug than if taken normally, and this is important because time is crucial to successfully treat a poisoning. The water-soluble nature of avizafone is also highly important in this regard.

IS AVIZAFONE SAFE?

As a prodrug of diazepam, avizafone carries certain risks inherent to all benzodiazepine compounds. However, when we examine the clinical context in which avizafone use takes place, fretting over its risks makes little sense. In simple terms, any possible side effects stemming from avizafone use pale compared to the effects of poising by nerve agents.

And in terms of avizafone’s abuse liability, this drug is not available on the market, and there is no significant record of black-market avizafone abuse.

SIDE EFFECTS OF AVIZAFONE

Avizafone is metabolized into diazepam very quickly, which means that what we’re trying to assess here is diazepam’s side effects.

The FDA has identified the following side effects as a result of the related substance, diazepam:

  • Firstly, Antegrade amnesia
  • Secondly, Anxiety
  • Thirdly, Blurred vision
  • In continuation, Changes in libido
  • Also, Changes in salivation
  • Emphasis, Confusion
  • Furthermore, Constipation
  • However, Depression
  • Next, Diplopia
  • Then, Dizziness
  • After, Dysarthria
  • Because, Elevated transaminases and alkaline phosphatase
  • In addition, Gastrointestinal disturbances
  • Hallucinations
  • Headache
  • Hypotension
  • Incontinence
  • Insomnia
  • Irritability
  • Nausea
  • Skin reactions
  • Slurred speech
  • Tremors
  • Urinary retention
  • Lastly, Vertigo

AVIZAFONE WITHDRAWAL AND DEPENDENCE

Physical dependence and withdrawal symptoms stemming from avizafone use should not be a meaningful concern. Certain benzodiazepines can engender dependence within a time frame as short as seven to 10 days, but in the case of single-use benzodiazepines like flumazenil or avizafone, the possibility of developing dependence is just not there.

AVIZAFONE SAFETY TIPS

The unique nature of avizafone also implies there is little to be gained by assessing it from a harm reduction lens.

So instead, we would rather remind everyone of the basic harm reduction recommendations applicable to more traditional benzodiazepines:

BENZODIAZEPINE HARM REDUCTION TIPS
  1. 🥣 Don’t mix — Mixing benzodiazepines with other depressants (alcohol, GHB, phenibut, barbiturates, opiates) can be fatal.
  2. ⏳ Take frequent breaks or plan for a short treatment span — Benzodiazepines can form dependence quickly, so it’s important to stop using the drug periodically.
  3. 🥄 Always stick to the proper dose — The dosage of benzos can vary substantially. Some drugs require 20 or 30 mg; others can be fatal in doses as low as 3 mg.
  4. 💊 Be aware of contraindications — Benzodiazepines are significantly more dangerous in older people or those with certain medical conditions.
  5. 🧪 Test your drugs — If ordering benzos from unregistered vendors (online or street vendors), order a benzo test kit to ensure your pills contain what you think they do.
  6. 💉 Never snort or inject benzos — Not only does this provide no advantage, but it’s also extremely dangerous. Benzos should be taken orally.
  7. 🌧 Recognize the signs of addiction — Early warning signs are feeling like you’re not “yourself” without the drug or hiding your habits from loved ones.
  8. ⚖️ Understand the laws where you live — In most parts of the world, benzodiazepines are only considered legal if given a prescription by a medical doctor.
  9. 📞 Know where to go if you need help — Help is available for benzodiazepine addiction; you just have to ask for it. Look up “addiction hotline” for more information where you live. (USA: 1-800-662-4357; Canada: 1-866-585-0445; UK: 0300-999-1212).

    AVIZAFONE USAGE INSTRUCTIONS

    Avizafone, a benzodiazepine derivative, is used primarily in emergency medicine, often for rapid intervention in seizures or as an antidote to nerve agents. When administering Avizafone, it’s essential to follow specific instructions, as it is typically available for intravenous (IV) or intramuscular (IM) use. Here’s a general guide:

    1. Dosage and Administration:
      • Dosage will depend on the individual’s weight, age, and medical condition, with adjustments made under the guidance of a healthcare provider.
      • Avizafone is typically administered intravenously for immediate effect in acute situations or intramuscularly when IV access is not available.
    2. Administration Protocol:
      • Intravenous (IV): Avizafone should be injected slowly to avoid potential complications.
      • Intramuscular (IM): For ease of use in emergencies, IM injections can be used to rapidly deliver the medication when immediate seizure relief or nerve agent reversal is required.
    3. Safety and Monitoring:
      • Vital signs should be monitored continuously during and after administration to manage potential side effects such as respiratory depression or hypotension.
      • Medical supervision is essential, especially in settings where Avizafone is used for nerve agent poisoning or seizure control.
    4. Follow-Up Care:
      • Follow-up care may include additional medications or treatments depending on the patient’s response to Avizafone.

    Important Note: Only qualified healthcare providers should administer Avizafone, given its potency and specialized use. Self-administration is not recommended due to the risk of severe side effects and the need for precise dosing.

    For specific dosing and safety details, always refer to the medication guidelines provided with the product or consult a healthcare provider.

AVIZAFONE DRUG INTERACTIONS

As a benzodiazepine with CNS-depressant properties, avizafone could be deadly when combined with other compounds like opioids or alcohol. Luckily, the unique nature of avizafone means there’s little chance of any such combination taking place.

AVIZAFONE DRUG CONTRAINDICATIONS

As a prodrug of diazepam, avizafone is contraindicated for the same conditions.

AVIZAFONE DOSAGE

Within the context of an antidote for organophosphate poisoning, the proper dose for avizafone is 20 mg.

SIMILAR BENZODIAZEPINES

In terms of its clinical objective, there aren’t many benzodiazepine compounds to which we could compare avizafone, but there are compounds that are meaningfully related to it in other ways.

FLUMAZENIL

It is a benzodiazepine receptor antagonist used in a comparable way to avizafone.

Flumazenil is also a single-use compound meant to be injected, but instead of treating nerve agent poisoning, flumazenil is used to revert the effects of benzodiazepine overdoses.

Flumazenil can do this because, as a receptor antagonist, it interacts with GABA receptors in the opposite way that most benzodiazepines do and thus works to lessen the effects of benzodiazepines in the body.

Flumazenil

DIAZEPAM

The comparison here is evident given that avizafone is a prodrug for diazepam (AKA Valium) and converts into it almost instantly. The pharmacological properties of diazepam help stop organophosphate poising, but it’s the pharmacokinetics of avizafone that allow these effects to be effective.

Diazepam

NATURAL ALTERNATIVES TO BENZODIAZEPINES

Natural alternatives to benzodiazepines exist! If you’re wondering if benzodiazepines might be too much of a risk, then why not give one of the following compounds a try?

KRATOM

You might’ve heard about kratom already, as this tropical evergreen plant has recently exploded in popularity. Indeed, prescription drug users of all kinds have begun switching over to kratom due to its incredible suite of pharmacological benefits.

Kratom is a spectrum drug, which means that as the dosage increases, the effects begin to change. In low doses, kratom is a stimulant and euphoric, while in mid-to-high doses, its an anxiolytic, analgesic, and sedative [3].

The only concern is that since kratom interacts with the body’s opioid receptors, it can become dangerous if mixed with other CNS-depressant compounds.

Kratom (Mitragyna speciosa)

ST. JOHN’S WORT

St. John’s wort is a flowering shrub that also boasts pharmacologic benefits, although not quite as diverse as kratom’s. It is mainly used as an anxiolytic, although it does have other benefits, like the treatment of menopausal symptoms [4].

However, St. John’s wort can cause dependence if taken in large amounts for an extended period. Additionally, it also interacts with many compounds, so it’s important to speak to a doctor before using it. Nevertheless, it’s effective in treating mild to moderate depression and produces fewer side effects than pharmacological alternatives!

FREQUENTLY ASKED QUESTIONS ABOUT AVIZAFONE

1. What is Avizafone used for?

Avizafone is primarily used as an antidote in cases of nerve agent exposure. It’s a benzodiazepine prodrug that converts to diazepam in the body. Providing rapid anticonvulsant effects crucial for military personnel and emergency responders dealing with nerve agent poisoning.

2. How is Avizafone administered?

Firstly, Avizafone is usually given as an intramuscular injection by medical professionals or in controlled emergency environments. Its injectable form allows for fast-acting effects, ideal in urgent scenarios. The dosage and administration must be conducted by trained personnel due to its powerful effects.

3. Is Avizafone available for civilian use?

Avizafone is not generally available for non-military or civilian use due to its specialized applications and the risks associated with misuse. Access typically requires authorization for specific professional use cases or is provided within emergency medical and military settings.

4. What are the side effects of Avizafone?

As with many benzodiazepines, Avizafone can cause side effects such as dizziness, drowsiness, and potentially respiratory depression, particularly if not used as directed. Side effects may vary depending on the dosage and the individual’s health condition. In cases of misuse or overdose, more severe effects can occur.

5. How does Avizafone differ from other benzodiazepines?

Unlike common benzodiazepines prescribed for anxiety or seizures, Avizafone is a prodrug specifically designed to counteract nerve agent toxicity. Its unique formulation allows for rapid conversion to diazepam, providing essential anticonvulsant effects during emergencies related to chemical exposure.

6. How should Avizafone be stored?

Avizafone should be stored in a cool, dry place, away from direct sunlight and out of reach of unauthorized individuals. Proper storage is essential to maintain its efficacy, especially in emergency contexts.

7. Can Avizafone be combined with other medications?

Avizafone may interact with other central nervous system depressants or medications that have similar sedative effects. It’s critical to consult medical professionals regarding any potential interactions. Also, before use, as combining Avizafone with certain medications can amplify side effects.

8. What are the legal considerations for Avizafone?

Due to its potent effects and application in nerve agent treatment, Avizafone’s availability is highly regulated. It’s primarily restricted to medical and military uses, and access may be limited based on jurisdiction and regulatory standards.

CONCLUSION

Purchasing Avizafone online can be a convenient solution for those needing access to this specialized benzodiazepine, primarily used for its rapid action in treating seizures and as an antidote in emergency situations involving nerve agents. When buying Avizafone online, it is essential to ensure you are using a reputable, licensed pharmacy to guarantee product authenticity, quality, and safe shipping practices. Proper guidance from medical professionals is advised to avoid any potential side effects or interactions and to ensure that Avizafone is used effectively and safely. Reliable online sources can provide a secure and discreet way to obtain this medication if prescribed or authorized, helping to support those who require it in urgent or regulated scenarios.

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